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Nickel‐Catalyzed, Regio‐ and Enantioselective Benzylic Alkenylation of Olefins with Alkenyl Bromide
Author(s) -
Liu Jiandong,
Gong Hegui,
Zhu Shaolin
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202012614
Subject(s) - enantioselective synthesis , chemoselectivity , chemistry , isomerization , catalysis , bromide , ligand (biochemistry) , organic chemistry , olefin fiber , nickel , medicinal chemistry , biochemistry , receptor
Abstract A NiH‐catalyzed migratory hydroalkenylation reaction of olefins with alkenyl bromides has been developed, affording benzylic alkenylation products with high yields and excellent chemoselectivity. The mild conditions of the reaction preclude olefinic products from undergoing further isomerization or subsequent alkenylation. Catalytic enantioselective hydroalkenylation of styrenes was achieved by using a chiral bisoxazoline ligand.