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Palladium‐Catalyzed Asymmetric Hydrosulfonylation of 1,3‐Dienes with Sulfonyl Hydrazides
Author(s) -
Li MingMing,
Cheng Lei,
Xiao LiJun,
Xie JianHua,
Zhou QiLin
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202012485
Subject(s) - chemistry , sulfonyl , palladium , allylic rearrangement , regioselectivity , phosphoramidite , catalysis , sulfone , hydrazine (antidepressant) , enantioselective synthesis , denticity , ligand (biochemistry) , combinatorial chemistry , organic chemistry , medicinal chemistry , crystal structure , dna , biochemistry , alkyl , receptor , chromatography , oligonucleotide
A highly enantio‐ and regioselective hydrosulfonylation of 1,3‐dienes with sulfonyl hydrazides has been realized by using a palladium catalyst containing a monodentate chiral spiro phosphoramidite ligand. The reaction provided an efficient approach to synthetically useful chiral allylic sulfones. Mechanistic studies suggest that the reaction proceeds through the formation of an allyl hydrazine intermediate and subsequent rearrangement to the chiral allylic sulfone product. The transformation of the allyl hydrazine intermediate to the product is the enantioselectivity‐determining step.
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