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Cobalt‐Catalyzed Markovnikov‐Type Selective Hydroboration of Terminal Alkynes
Author(s) -
Chen Jieping,
Shen Xuzhong,
Lu Zhan
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202012164
Subject(s) - markovnikov's rule , hydroboration , chemistry , alkene , regioselectivity , catalysis , cobalt , hydride , combinatorial chemistry , ligand (biochemistry) , organic chemistry , medicinal chemistry , metal , biochemistry , receptor
A cobalt‐catalyzed Markovnikov‐type hydroboration of terminal alkynes with HBpin to access α‐alkenyl boronates with good regioselectivity and atom economy is reported. A new ligand has been developed for the cobalt hydride catalyst that has been used for a unique Markovnikov selective insertion of terminal alkynes into metal hydride bond. This operationally simple protocol exhibits excellent functional group tolerance to deliver valuable alkene derivatives.