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Amino‐Supported Palladium Catalyst for Chemo‐ and Stereoselective Domino Reactions
Author(s) -
Li ManBo,
Yang Jie,
Yang Ying,
Xu GuoYong,
Luo Gen,
Yang Jianping,
Bäckvall JanE.
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202011708
Subject(s) - chemoselectivity , catalysis , palladium , domino , chemistry , alkyne , stereoselectivity , cascade reaction , combinatorial chemistry , borylation , heterogeneous catalysis , organic chemistry , aryl , alkyl
Abstract A solid amino‐supported palladium catalyst is used in an oxidative domino reaction for the diastereoselective construction of alkyne‐substituted cyclopentenol compounds. This heterogeneous catalyst exhibits high efficiency and excellent chemoselectivity, as well as good recyclability. The chemoselectivity of the domino reactions was readily controlled by switching the solvent and catalyst. Asymmetric syntheses and an oxidative carbocyclization‐borylation reaction have also been developed based on the heterogeneous palladium catalyst.