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Single‐Scan Selective Excitation of Individual NMR Signals in Overlapping Multiplets
Author(s) -
Kiraly Peter,
Kern Nicolas,
Plesniak Mateusz P.,
Nilsson Mathias,
Procter David J.,
Morris Gareth A.,
Adams Ralph W.
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202011642
Subject(s) - excitation , chemistry , nuclear magnetic resonance spectroscopy , materials science , nuclear magnetic resonance , computational chemistry , physics , stereochemistry , quantum mechanics
2D NMR is an immensely powerful structural tool but it is time‐consuming. Targeting individual chemical groups by selective excitation in a 1D experiment can give the information required far more quickly. A major problem, however, is that proton NMR spectra are often extensively overlapped, so that in practice only a minority of sites can be selectively excited. Here we overcome that problem using a fast, single‐scan method that allows selective excitation of the signals of a single proton multiplet even where it is severely overlapped by other multiplets. The advantages of the method are illustrated in a selective 1D NOESY experiment, the most efficient way to determine relative configuration unambiguously by NMR. The new approach presented here has the potential to broaden significantly the applicability of selective excitation and unlock its real potential for many other experiments.