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Enantioselective Intermolecular Heck and Reductive Heck Reactions of Aryl Triflates, Mesylates, and Tosylates Catalyzed by Nickel
Author(s) -
Huang Xiaolei,
Teng Shenghan,
Chi Yonggui Robin,
Xu Wenqiang,
Pu Maoping,
Wu YunDong,
Zhou Jianrong Steve
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202011036
Subject(s) - heck reaction , aryl , chemistry , enantioselective synthesis , nickel , catalysis , cyclopentenone , organic chemistry , conjugate , enone , medicinal chemistry , palladium , mathematical analysis , alkyl , mathematics
Nickel‐catalyzed intermolecular Heck reaction of cycloalkenes proceeds well with aryl triflates, mesylates and tosylates in excellent enantiomeric ratios. The asymmetric reductive Heck reaction also works with a 2‐cyclopentenone ketal, which is equivalent to conjugate arylation of the enone itself.