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Ligand‐Dependent Activity Engineering of Glutathione Peroxidase‐Mimicking MIL‐47(V) Metal–Organic Framework Nanozyme for Therapy
Author(s) -
Wu Jiangjiexing,
Yu Yijun,
Cheng Yuan,
Cheng Chaoqun,
Zhang Yihong,
Jiang Bo,
Zhao Xiaozhi,
Miao Leiying,
Wei Hui
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202010714
Subject(s) - glutathione peroxidase , ligand (biochemistry) , chemistry , in vivo , metal organic framework , peroxidase , reactive oxygen species , glutathione , combinatorial chemistry , biophysics , biochemistry , enzyme , receptor , organic chemistry , biology , adsorption , microbiology and biotechnology
Glutathione peroxidase (GPx) plays an important role in maintaining the reactive oxygen metabolic balance, yet limited GPx‐mimicking nanozymes are currently available for in vivo therapy. Herein, a ligand engineering strategy is developed to modulate the GPx‐mimicking activity of a metal–organic framework (MOF) nanozyme. With different substituted ligands, the GPx‐mimicking activities of MIL‐47(V)‐X (MIL stands for Materials of Institute Lavoisier; X=F, Br, NH 2 , CH 3 , OH, and H) MOFs are rationally regulated. With the best one as an example, both in vitro and in vivo experiments reveal the excellent antioxidation ability of MIL‐47(V)‐NH 2 , which alleviates the inflammatory response effectively for both ear injury and colitis, and is more active than MIL‐47(V). This study proves that high‐performance GPx‐mimicking nanozymes can be rationally designed by a ligand engineering strategy, and that structure–activity relationships can direct the in vivo therapy. This study enriches nanozyme research and expands the range of biomimetic MOFs.