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An Innovative Hydrogen Peroxide‐Sensing Scaffold and Insight Towards its Potential as an ROS‐Activated Persulfide Donor
Author(s) -
Hankins Rynne A.,
Suarez S. Israel,
Kalk Madison A.,
Green Nolan M.,
Harty Megan N.,
Lukesh John C.
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202010530
Subject(s) - hydrogen peroxide , chemistry , reactive oxygen species , electrophile , scaffold , hydrogen sulfide , oxidative stress , catalysis , combinatorial chemistry , sulfur , reactive intermediate , biochemistry , organic chemistry , medicine , biomedical engineering
Reactive sulfur species, such as hydrogen sulfide, persulfides, and polysulfides, have recently emerged as key signaling molecules and important physiological mediators within mammalian systems. To better assess the therapeutic potential of their exogenous administration, we report on the development of a unique hydrogen peroxide (H 2 O 2 )‐sensing motif and its capacity for providing cellular protection against oxidative stress while serving as a reactive oxygen species (ROS)‐activated persulfide donor. With the strategic implementation of a gem ‐dimethyl group to promote both stability and cyclization, we found the initial rate of payload release from this newly derived scaffold to be directly proportional to the concentration of H 2 O 2 and to proceed via an unprecedented pathway that avoids the production of electrophilic byproducts, a severe limitation that has plagued the physiological application of previous designs.