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Transition‐Metal‐Free Cross‐Coupling by Using Tertiary Benzylic Organoboronates
Author(s) -
Takeda Mitsutaka,
Nagao Kazunori,
Ohmiya Hirohisa
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202010251
Subject(s) - alkyl , electrophile , aryl , chemistry , transition metal , alkoxide , coupling reaction , metal , electrophilic substitution , polymer chemistry , organic chemistry , catalysis
The transition‐metal‐free cross‐coupling of alkyl or aryl electrophiles by using tertiary benzylic organoboronates is reported. This reaction involves the generation of tertiary alkyl anions from organoboronates in the presence of an alkoxide base and then their substitution reactions. This protocol allows the simple and efficient construction of quaternary carbon centers.