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Single‐Carbon‐Fiber‐Powered Microsensor for In Vivo Neurochemical Sensing with High Neuronal Compatibility
Author(s) -
Yu Ping,
Wei Huan,
Zhong Peipei,
Xue Yifei,
Wu Fei,
Liu Yang,
Fei Junjie,
Mao Lanqun
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202010195
Subject(s) - neurochemical , compatibility (geochemistry) , in vivo , nanotechnology , ascorbic acid , chemistry , materials science , neuroscience , biology , microbiology and biotechnology , food science , composite material
The development of new principles and techniques with high neuronal compatibility for quantitatively monitoring the dynamics of neurochemicals is essential for deciphering brain chemistry and function but remains a great challenge. We herein report a neuron‐compatible method for in vivo neurochemical sensing by powering a single carbon fiber through spontaneous bipolar electrochemistry as a new sensing platform. By using ascorbic acid as a model target to prove the concept, we found that the single‐carbon‐fiber‐powered microsensor exhibited a good response, high stability and, more importantly, excellent neuronal compatibility. The microsensor was also highly compatible with electrophysiological recording, thus enabling the synchronous recording of both chemical and electrical signals. The sensing principle could be developed for in vivo monitoring of various neurochemicals in the future by rationally designing and tuning the electrochemical reactions at the two poles of the carbon fiber.