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Dual‐Emissive Platinum(II) Metallacage with a Sensitive Oxygen Response for Imaging of Hypoxia and Imaging‐Guided Chemotherapy
Author(s) -
Zhu Huangtianzhi,
Li Qi,
Shi Bingbing,
Ge Fujing,
Liu Yuezhou,
Mao Zhengwei,
Zhu Hong,
Wang Sheng,
Yu Guocan,
Huang Feihe,
Stang Peter J.
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202009442
Subject(s) - tumor hypoxia , in vivo , hypoxia (environmental) , fluorescence lifetime imaging microscopy , imaging agent , chemotherapy , phosphorescence , chemistry , fluorescence , preclinical imaging , biophysics , materials science , biomedical engineering , cancer research , oxygen , medicine , radiation therapy , radiology , biology , physics , microbiology and biotechnology , organic chemistry , quantum mechanics
Imaging of hypoxia in vivo helps with accurate cancer diagnosis and evaluation of therapeutic outcomes. A Pt II metallacage with oxygen‐responsive red phosphorescence and steady fluorescence for in vivo hypoxia imaging and chemotherapy is reported. The therapeutic agent and diagnostic probe were integrated into the metallacage through heteroligation‐directed self‐assembly. Nanoformulation by encapsulating the metallacage into nanoparticles greatly enhanced its stability the in physiological environment, rendering biomedical applications feasible. Apart from enhanced red phosphorescence upon hypoxia, the ratio between red and blue emissions, which only varies with intracellular oxygen level, provides a more precise standard for hypoxia imaging and detection. Moreover, in vivo explorations demonstrate the promising potential applications of the metallacage‐loaded nanoparticles as theranostic agents for tumor hypoxia imaging and chemotherapy.