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Spatio‐Temporally Reporting Dose‐Dependent Chemotherapy via Uniting Dual‐Modal MRI/NIR Imaging
Author(s) -
Ma Yiyu,
Yan Chenxu,
Guo Zhiqian,
Tan Guang,
Niu Dechao,
Li Yongsheng,
Zhu WeiHong
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202009380
Subject(s) - in vivo , magnetic resonance imaging , fluorescence , fluorescence lifetime imaging microscopy , chemistry , biophysics , photodynamic therapy , hydroxyl radical , intracellular , nuclear magnetic resonance , biochemistry , medicine , radiology , physics , biology , optics , radical , microbiology and biotechnology , organic chemistry
Unpredictable in vivo therapeutic feedback of hydroxyl radical ( . OH) efficiency is the major bottleneck of chemodynamic therapy. Herein, we describe novel Fenton‐based nanotheranostics NQ‐Cy@Fe&GOD for spatio‐temporally reporting intratumor . OH‐mediated treatment, which innovatively unites dual‐channel near‐infrared (NIR) fluorescence and magnetic resonance imaging (MRI) signals. Specifically, MRI signal traces the dose distribution of Fenton‐based iron oxide nanoparticles (IONPs) with high‐spatial resolution, meanwhile timely fluorescence signal quantifies . OH‐mediated therapeutic response with high spatio‐temporal resolution. NQ‐Cy@Fe&GOD can successfully monitor the intracellular release of IONPs and . OH‐induced NQO1 enzyme in living cells and tumor‐bearing mice, which makes a breakthrough in conquering the inherent unpredictable obstacles on spatio‐temporally reporting chemodynamic therapy, so as to manipulate dose‐dependent therapeutic process.