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Light‐Promoted Copper‐Catalyzed Enantioselective Alkylation of Azoles
Author(s) -
Li Chen,
Chen Bin,
Ma Xiaodong,
Mo Xueling,
Zhang Guozhu
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202009323
Subject(s) - alkylation , enantioselective synthesis , chemistry , catalysis , reactivity (psychology) , alkyl , copper , combinatorial chemistry , carbazole , surface modification , organic chemistry , medicine , alternative medicine , pathology
A catalytic asymmetric alkylation of azoles with secondary 1‐arylalkyl bromides through direct C−H functionalization is reported. Under blue‐light photoexcitation, a copper(I)/carbazole‐based bisoxazoline (CbzBox) catalytic system exhibits good reactivity and high stereoselectivity, thus offering an efficient strategy for the construction of chiral alkyl azoles. These reactions proceed at low temperature and are compatible with a wide range of azoles.