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Smart Magnetic and Fluorogenic Photosensitizer Nanoassemblies Enable Redox‐Driven Disassembly for Photodynamic Therapy
Author(s) -
An Ruibing,
Cheng Xiaoyang,
Wei Shixuan,
Hu Yuxuan,
Sun Yidan,
Huang Zheng,
Chen HongYuan,
Ye Deju
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202009141
Subject(s) - photosensitizer , photodynamic therapy , chemistry , in vivo , fluorescence , gadolinium , glutathione , biophysics , redox , photochemistry , biochemistry , enzyme , organic chemistry , physics , microbiology and biotechnology , quantum mechanics , biology
Stimuli‐responsive smart photosensitizer (PS) nanoassemblies that allow enhanced delivery and controlled release of PSs are promising for imaging‐guided photodynamic therapy (PDT) of tumors. However, the lack of high‐sensitivity and spatial‐resolution signals and fast washout of released PSs from tumor tissues have impeded PDT efficacy in vivo. Herein, we report tumor targeting, redox‐responsive magnetic and fluorogenic PS nanoassemblies ( NP‐RGD ) synthesized via self‐assembly of a cRGD‐ and disulfide‐containing fluorogenic and paramagnetic small molecule ( 1‐RGD ) for fluorescence/magnetic resonance bimodal imaging‐guided tumor PDT. NP‐RGD show high r 1 relaxivity but quenched fluorescence and PDT activity; disulfide reduction by glutathione (GSH) promotes efficient disassembly into a small‐molecule probe ( 2‐RGD ) and an organic PS (PPa‐SH), which could further bind with intracellular albumin, allowing prolonged retention and cascade activation of fluorescence and PDT to ablate tumors.