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Alkylation‐Terminated Catellani Reactions Using Alkyl Carbagermatranes
Author(s) -
Jiang WeiTao,
Xu MengYu,
Yang Shuo,
Xie XiuYing,
Xiao Bin
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202008482
Subject(s) - alkylation , alkyl , nucleophile , chemistry , electrophile , reactivity (psychology) , derivatization , organic chemistry , catalysis , medicine , alternative medicine , high performance liquid chromatography , pathology
The Catellani reaction has received substantial attention because it enables rapid multiple derivatization on aromatics. While using alkyl electrophiles to achieve ortho ‐alkylation was one of the earliest applications of the Catellani reaction, ipso ‐alkylation‐terminated reactions with β ‐H‐containing reactants has not been realized to date. Herein, we report alkylation‐terminated Catellani reaction using alkyl carbagermatranes (abbreviated as alkyl‐ Ge ) as nucleophiles. The reactivity of alkyl‐ Ge and alkyl‐B(OH) 2 in this reaction is discussed. This approach enables efficient dialkylation with β ‐H‐containing reactants, which was previously inaccessible by Catellani reactions.