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Postsynthetic Functionalization of DNA‐Nanocomposites with Proteins Yields Bioinstructive Matrices for Cell Culture Applications
Author(s) -
Hu Yong,
Domínguez Carmen M.,
Christ Sophina,
Niemeyer Christof M.
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202008471
Subject(s) - surface modification , nanocomposite , nanotechnology , dna , nanostructure , membrane , modular design , nanoparticle , polymer , materials science , nanometre , chemistry , combinatorial chemistry , computer science , biochemistry , organic chemistry , composite material , operating system
We report on the directed postsynthetic functionalization of soft DNA nanocomposite materials with proteins. Using the example of the functionalization of silica nanoparticle‐modified DNA polymer materials with agonists or antagonists of the epidermal growth factor receptor EGFR cell membrane receptor, we demonstrate that hierarchically structured interfaces to living cells can be established. Owing to the modular design principle, even complex DNA nanostructures can be integrated into the materials, thereby enabling the high‐precision arrangement of ligands on the lower nanometer length scale. We believe that such complex biohybrid material systems can be used for new applications in biotechnology.