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A Voltage‐Responsive Synthetic Cl − ‐Channel Regulated by pH
Author(s) -
Zheng ShaoPing,
Jiang JiJun,
Lee Arie,
Barboiu Mihail
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202008393
Subject(s) - chemistry , protonation , light gated ion channel , ion , ion channel , lipid bilayer , antiporter , membrane , ion transporter , transmembrane channels , transmembrane protein , voltage gated ion channel , biophysics , biochemistry , organic chemistry , receptor , biology
Transmembrane protein channels are an important inspiration for the design of artificial ion channels. Their dipolar structure helps overcome the high energy barrier to selectively translocate water and ions sharing one pathway, across the cell membrane. Herein, we report that the amino‐imidazole (Imu) amphiphiles self‐assemble via multiple H‐bonding to form stable artificial Cl − ‐channels within lipid bilayers. The alignment of water/Cl − wires influences the conduction of ions, envisioned to diffuse along the hydrophilic pathways; at acidic pH, Cl − /H + symport conducts along a partly protonated channel, while at basic pH, higher Cl − /OH − antiport translocate through a neutral channel configuration, which can be greatly activated by applying strong electric field. This voltage/pH regulated channel system represents an unexplored alternative for ion‐pumping along artificial ion‐channels, parallel to that of biology.