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Intrinsic Apyrase‐Like Activity of Cerium‐Based Metal–Organic Frameworks (MOFs): Dephosphorylation of Adenosine Tri‐ and Diphosphate
Author(s) -
Yang Jian,
Li Ke,
Li Chunzhong,
Gu Jinlou
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202008259
Subject(s) - apyrase , chemistry , dephosphorylation , adenosine triphosphate , adenosine diphosphate , atp hydrolysis , enzyme , hydrolysis , cerium , biochemistry , biophysics , organic chemistry , platelet , phosphatase , platelet aggregation , biology , atpase , immunology
Abstract Apyrase is an important family of extracellular enzymes that catalyse the hydrolysis of high‐energy phosphate bonds (HEPBs) in ATP and ADP, thereby modulating many physiological processes and driving life activities. Herein, we report an unexpected discovery that cerium‐based metal–organic frameworks (Ce‐MOFs) of UiO‐66(Ce) have intrinsic apyrase‐like activity for ATP/ADP‐related physiological processes. The abundant Ce III /Ce IV couple sites of Ce‐MOFs endow them with the ability to selectively catalyse the hydrolysis of HEPBs of ATP and ADP under physiological conditions. Compared to natural enzymes, they could resist extreme pH and temperature, and present a broad range of working conditions. Based on this finding, a significant inhibitory effect on ADP‐induced platelet aggregation was observed upon exposing the platelet‐rich plasma (PRP) to the biomimetic UiO‐66(Ce) films, prefiguring their wide application potentials in medicine and biotechnology.