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Chiral Cyclopentadienyl Ligands: Design, Syntheses, and Applications in Asymmetric Catalysis
Author(s) -
MasRoselló Josep,
Herraiz Ana G.,
Audic Benoît,
Laverny Aragorn,
Cramer Nicolai
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202008166
Subject(s) - enantioselective synthesis , cyclopentadienyl complex , combinatorial chemistry , ligand (biochemistry) , enantiomer , chemistry , catalysis , molecule , organic synthesis , surface modification , stereochemistry , organic chemistry , biochemistry , receptor
The creation of new chiral ligands capable of providing high stereocontrol in metal‐catalyzed reactions is crucial in modern organic synthesis. The production of bioactive molecules as single enantiomers is increasingly required, and asymmetric catalysis with metal complexes constitutes one of the most efficient synthetic strategies to access optically active compounds. Herein we offer a historical overview on the development of chiral derivatives of the ubiquitous cyclopentadienyl ligand (Cp X ), and detail their successful application in a broad range of metal‐catalyzed transformations. Those include the functionalization of challenging C−H bonds and beyond, giving access to an extensive catalogue of valuable chiral molecules. A critical comparison of the existing ligand families, their design, synthesis, and complexation to different metals is also provided. In addition, future research directions are discussed to further enhance the performance and application of Cp X ligands in enantioselective catalysis.