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X‐ray Crystallographic Observation of Chiral Transformations within a Metal–Peptide Pore
Author(s) -
Saito Ami,
Sawada Tomohisa,
Fujita Makoto
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202007731
Subject(s) - chirality (physics) , crystallography , folding (dsp implementation) , metal , chemistry , hemiacetal , x ray , peptide , materials science , stereochemistry , organic chemistry , chiral symmetry , physics , engineering , quantum mechanics , nambu–jona lasinio model , electrical engineering , quark , biochemistry
Porous metal complexes enable single‐crystal X‐ray crystallographic observation of included guests or reaction intermediates through simple soaking with the guests/substrates. Previous studies on this technique have often encountered difficulties in the observation of chiral structures because the host frameworks had no chirality. We synthesized a new metal–peptide porous complex through a folding‐and‐assembly strategy and utilized the chiral pore for trapping chiral guests. Chiral alcohols and ketones were successfully included within the pore. Crystallographic analyses clearly revealed not only their chemical structures but also chiral transformation events within the pore such as fixed conformations or an unstable hemiacetal formation.