Premium
One‐Pot Tandem Michael Addition/Enantioselective Conia‐Ene Cyclization Mediated by Chiral Iron(III)/Silver(I) Cooperative Catalysis
Author(s) -
Horibe Takahiro,
Sakakibara Masato,
Hiramatsu Rin,
Takeda Kazuki,
Ishihara Kazuaki
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202007180
Subject(s) - enantioselective synthesis , chemistry , tandem , catalysis , ene reaction , yield (engineering) , michael reaction , methylene , alkyl , proline , organic chemistry , organocatalysis , combinatorial chemistry , medicinal chemistry , amino acid , materials science , biochemistry , metallurgy , composite material
The first one‐pot tandem Michael addition/enantioselective Conia‐ene cyclization of N‐protected prop‐2‐yn‐1‐amines with 2‐methylene‐3‐oxoalkanoates promoted by chiral iron(III)/silver(I) cooperative catalysts has been developed. Alkyl 4‐methylenepyrrolidine‐3‐acyl‐3‐carboxylates, which can be transformed into β‐proline derivatives, are obtained in high yield with high enantioselectivity.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom