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Palladium‐Catalyzed Electrophilic Functionalization of Pyridine Derivatives through Phosphonium Salts
Author(s) -
Che YuanYuan,
Yue Yanni,
Lin LingZhi,
Pei Bingbing,
Deng Xuezu,
Feng Chao
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202006724
Subject(s) - transmetalation , phosphonium , electrophile , pyridine , chemistry , palladium , combinatorial chemistry , surface modification , phosphonium salt , catalysis , metalation , organic chemistry
Herein, we report a highly efficient and practical method for pyridine‐derived heterobiaryl synthesis through palladium‐catalyzed electrophilic functionalization of easily available pyridine‐derived quaternary phosphonium salts. The nice generality of this reaction was goes beyond arylation, enabling facile incorporation of diverse carbon‐based fragments, including alkenyl, alkynyl, and also allyl fragments, onto the pyridine core. Notably, the silver salt additive is revealed to be of vital importance for the success of this transformation and its pivotal role as transmetallation mediator, which guarantees a smooth transfer of pyridyl group to palladium intermediate, is also described.