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Stimuli‐Responsive Cycloaurated “OFF‐ON” Switchable Anion Transporters
Author(s) -
Fares Mohamed,
Wu Xin,
Ramesh Deepthi,
Lewis William,
Keller Paul A.,
Howe Ethan N. W.,
PérezTomás Ricardo,
Gale Philip A.
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202006392
Subject(s) - transporter , chemistry , organic anion transporter 1 , homeostasis , function (biology) , biophysics , glutathione , cancer cell , combinatorial chemistry , biochemistry , microbiology and biotechnology , cancer , biology , genetics , gene , enzyme
Anion transporters have shown potential application as anti‐cancer agents that function by disrupting homeostasis and triggering cell death. In this research article we report switchable anion transport by gold complexes of anion transporters that are “switched on” in situ in the presence of the reducing agent GSH by decomplexation of gold. GSH is found in higher concentrations in tumors than in healthy tissue and hence this approach offers a strategy to target these systems to tumors.