Stereoselective Electro‐2‐deoxyglycosylation from Glycals | Zendy

Liu Miao | Zendy; Liu KaiMeng | Zendy; Xiong DeCai | Zendy; Zhang Hanyu | Zendy; Li Tian | Zendy; Li Bohan | Zendy; Qin Xianjin | Zendy; Bai Jinhe | Zendy; Ye XinShan | Zendy

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Stereoselective Electro‐2‐deoxyglycosylation from Glycals

Author(s) -

Liu Miao,

Liu KaiMeng,

Xiong DeCai,

Zhang Hanyu,

Li Tian,

Li Bohan,

Qin Xianjin,

Bai Jinhe,

Ye XinShan

Publication year - 2020

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.202006115

Subject(s) - stereoselectivity , chemistry , trisaccharide , podophyllotoxin , combinatorial chemistry , glycosylation , stereochemistry , organic chemistry , catalysis , biochemistry

We report a novel and highly stereoselective electro‐2‐deoxyglycosylation from glycals. This method features excellent stereoselectivity, scope, and functional‐group tolerance. This process can also be applied to the modification of a wide range of natural products and drugs. Furthermore, a scalable synthesis of glycosylated podophyllotoxin and a one‐pot trisaccharide synthesis through iterative electroglycosylations were achieved.

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