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Stereoselective Electro‐2‐deoxyglycosylation from Glycals
Author(s) -
Liu Miao,
Liu KaiMeng,
Xiong DeCai,
Zhang Hanyu,
Li Tian,
Li Bohan,
Qin Xianjin,
Bai Jinhe,
Ye XinShan
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202006115
Subject(s) - stereoselectivity , chemistry , trisaccharide , podophyllotoxin , combinatorial chemistry , glycosylation , stereochemistry , organic chemistry , catalysis , biochemistry
We report a novel and highly stereoselective electro‐2‐deoxyglycosylation from glycals. This method features excellent stereoselectivity, scope, and functional‐group tolerance. This process can also be applied to the modification of a wide range of natural products and drugs. Furthermore, a scalable synthesis of glycosylated podophyllotoxin and a one‐pot trisaccharide synthesis through iterative electroglycosylations were achieved.