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Autonomous Growth of a Spatially Localized Supramolecular Hydrogel with Autocatalytic Ability
Author(s) -
Rodon Fores Jennifer,
CriadoGonzalez Miryam,
Chaumont Alain,
Carvalho Alain,
Blanck Christian,
Schmutz Marc,
Boulmedais Fouzia,
Schaaf Pierre,
Jierry Loïc
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202005377
Subject(s) - autocatalysis , supramolecular chemistry , nanotechnology , self assembly , nanofiber , synthetic biology , chemistry , autocatalytic reaction , biophysics , materials science , catalysis , biochemistry , computational biology , molecule , biology , physics , organic chemistry , statistical physics
Autocatalysis and self‐assembly are key processes in developmental biology and are involved in the emergence of life. In the last decade both of these features were extensively investigated by chemists with the final goal to design synthetic living systems. Herein, we describe the autonomous growth of a self‐assembled soft material, that is, a supramolecular hydrogel, able to sustain its own formation through an autocatalytic mechanism that is not based on any template effect and emerges from a peptide (hydrogelator) self‐assembly. A domino sequence of events starts from an enzymatically triggered peptide generation followed by self‐assembly into catalytic nanofibers that induce and amplify their production over time, resulting in a 3D hydrogel network. A cascade is initiated by traces (10 −18 m ) of a trigger enzyme, which can be localized allowing for a spatial resolution of this autocatalytic buildup of hydrogel growth, an essential condition on the route towards further cell‐mimic designs.