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Construction of Liposomes Mimicking Cell Membrane Structure through Frame‐Guided Assembly
Author(s) -
Wang Chao,
Piao Jiafang,
Li Yujie,
Tian Xiancheng,
Dong Yuanchen,
Liu Dongsheng
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202005334
Subject(s) - liposome , transmembrane protein , lipid bilayer , biophysics , cytoskeleton , drug delivery , biocompatibility , chemistry , membrane , bilayer , cell membrane , cell , nanotechnology , biochemistry , materials science , biology , receptor , organic chemistry
The shape of eukaryotic cells is determined by the cytoskeleton associated with membrane proteins; however, the detailed mechanism of how the integral morphologies with structural stability is generated and maintained is still not fully understood. Here, based on the Frame‐Guided Assembly (FGA) strategy, we successfully prepared hetero‐liposomes with structural composition similar to that of eukaryotic cells by screening a series of transmembrane peptides as the leading hydrophobic groups (LHGs). It was demonstrated that the conformation and transmembrane mode of the LHGs played dominant roles during the FGA process. The FGA liposomes were formed with excellent stability, which may further provide evidence for the cytoskeleton–membrane protein–lipid bilayer model. Taking advantage of the biocompatibility and stability, the FGA liposomes were also applied to prepare novel drug delivery vehicles, which is promising in diagnostic imaging and cancer therapy applications.