Organocatalytic Enantioselective Synthesis of Atropisomeric Aryl‐ p ‐Quinones: Platform Molecules for Diversity‐Oriented Synthesis of Biaryldiols

Presented here is a class of novel axially chiral aryl‐ p ‐quinones as platform molecules for the preparation of non‐ C 2 symmetric biaryldiols. Two sets of aryl‐ p ‐quinone frameworks were synthesized with remarkable enantiocontrol by means of chiral phosphoric acid catalyzed enantioselective arylation of p ‐quinones by central‐to‐axial chirality conversion. These aryl‐ p ‐quinones were then used to access a wide spectrum of highly functionalized non‐ C 2 symmetric biaryldiols with excellent retention of the enantiopurity.