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Revealing Silylation of C(sp 2 )/C(sp 3 )–H Bonds in Arylphosphines by Ruthenium Catalysis
Author(s) -
Wen Jian,
Dong Ben,
Zhu Jinjun,
Zhao Yue,
Shi Zhuangzhi
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202003865
Subject(s) - silylation , ruthenium , chemistry , catalysis , chelation , selectivity , surface modification , medicinal chemistry , organic chemistry
The first aromatic C−H silylation between arylphosphines and hydrosilanes enabled by a ruthenium complex has been developed. The excellent ortho ‐selectivity results from a four‐membered metallacyclic intermediate involving phosphorus chelation. The developed system can be extended to the benzylic C−H silylation of arylphosphines. Diverse silylated arylphosphines are produced, exhibiting broad functional group compatibility. Further functionalization of the products under mild conditions renders the formed compounds useful building blocks.