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Nucleic Acid Aptamers for Molecular Diagnostics and Therapeutics: Advances and Perspectives
Author(s) -
Li Long,
Xu Shujuan,
Yan He,
Li Xiaowei,
Yazd Hoda Safari,
Li Xiang,
Huang Tong,
Cui Cheng,
Jiang Jianhui,
Tan Weihong
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202003563
Subject(s) - aptamer , systematic evolution of ligands by exponential enrichment , computational biology , nanotechnology , biomedicine , computer science , biology , bioinformatics , microbiology and biotechnology , rna , materials science , biochemistry , gene
The advent of SELEX (systematic evolution of ligands by exponential enrichment) technology has shown the ability to evolve artificial ligands with affinity and specificity able to meet growing clinical demand for probes that can, for example, distinguish between the target leukemia cells and other cancer cells within the matrix of heterogeneity, which characterizes cancer cells. Though antibodies are the conventional and ideal choice as a molecular recognition tool for many applications, aptamers complement the use of antibodies due to many unique advantages, such as small size, low cost, and facile chemical modification. This Minireview will focus on the novel applications of aptamers and SELEX, as well as opportunities to develop molecular tools able to meet future clinical needs in biomedicine.