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Iridium(III) Catalysts with an Amide‐Pendant Cyclopentadienyl Ligand: Double Aromatic Homologation Reactions of Benzamides by Fourfold C−H Activation
Author(s) -
Tomita Eiki,
Yamada Kodai,
Shibata Yu,
Tanaka Ken,
Kojima Masahiro,
Yoshino Tatsuhiko,
Matsunaga Shigeki
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202003009
Subject(s) - cyclopentadienyl complex , iridium , chemistry , amide , catalysis , ligand (biochemistry) , yield (engineering) , medicinal chemistry , organic chemistry , receptor , materials science , biochemistry , metallurgy
The synthesis, characterization, and catalytic performance of iridium(III) catalysts that bear an amide‐pendant cyclopentadienyl ligand ([Cp A IrI 2 ] 2 ) is reported. These [Cp A IrI 2 ] 2 catalysts were obtained from the complexation of a Cp A ligand precursor with [Ir(cod)OAc] 2 followed by oxidation. Double aromatic homologation reactions of benzamides with alkynes by fourfold C−H activation proceeded in good to high yield with these [Cp A IrI 2 ] 2 catalysts, demonstrating their superior catalytic performance in this challenging transformation.