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Semiconducting Polycomplex Nanoparticles for Photothermal Ferrotherapy of Cancer
Author(s) -
He Shasha,
Jiang Yuyan,
Li Jingchao,
Pu Kanyi
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202003004
Subject(s) - photothermal therapy , ethylene glycol , nanoparticle , photothermal effect , radical , chelation , amphiphile , chemistry , photoacoustic imaging in biomedicine , materials science , photochemistry , nanotechnology , biophysics , polymer , organic chemistry , copolymer , biology , physics , optics
This study reports the development of iron‐chelated semiconducting polycomplex nanoparticles (SPFeN) for photoacoustic (PA) imaging‐guided photothermal ferrotherapy of cancer. The hybrid polymeric nanoagent comprises a ferroptosis initiator (Fe 3+ ) and an amphiphilic semiconducting polycomplex (SP C ) serving as both the photothermal nanotransducer and iron ion chelator. By virtue of poly(ethylene glycol) (PEG) grafting and its small size, SPFeN accumulates in the tumor of living mice after systemic administration, which can be monitored by PA imaging. In the acidic tumor microenvironment, SPFeN generates hydroxyl radicals, leading to ferroptosis; meanwhile, under NIR laser irradiation, it generates localized heat to not only accelerate the Fenton reaction but also implement photothermal therapy. Such a combined photothermal ferrotherapeutic effect of SPFeN leads to minimized dosage of iron compared to previous studies and effectively inhibits the tumor growth in living mice, which is not possible for the controls.