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Iridium‐Catalyzed β‐Alkynylation of Aliphatic Oximes as Masked Carbonyl Compounds and Alcohols
Author(s) -
Tan Eric,
Zanini Margherita,
Echavarren Antonio M.
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202002948
Subject(s) - alkynylation , catalysis , chemistry , iridium , oxime , organic chemistry , molecule , ketone , primary (astronomy) , medicinal chemistry , physics , astronomy
An Ir‐catalyzed C(sp 3 )−H alkynylation of aliphatic ketones, aldehydes, and alcohols was achieved by using the corresponding oxime derivatives and a Ir III catalyst. This general reaction is selective towards primary C(sp 3 )−H bonds and can be used for the late‐stage C−H alkynylation of complex molecules.