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SERS‐Active MIL‐100(Fe) Sensory Array for Ultrasensitive and Multiplex Detection of VOCs
Author(s) -
Fu JingHao,
Zhong Zhen,
Xie Dan,
Guo YanJun,
Kong DeXuan,
Zhao ZhongXing,
Zhao ZhenXia,
Li Min
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202002720
Subject(s) - detection limit , multiplex , substrate (aquarium) , toluene , nanotechnology , materials science , nanoparticle , chemistry , combinatorial chemistry , chromatography , organic chemistry , bioinformatics , oceanography , biology , geology
The application of metal–organic frameworks (MOFs) as SERS‐active platforms in multiplex volatile organic compounds (VOCs) detection is still unexplored. Herein, we demonstrate that MIL‐100 (Fe) serves as an ideal SERS substrate for the detection of VOCs. The limit of detection (LOD) of MIL‐100(Fe) for toluene sensing can reach 2.5 ppm, and can be even further decreased to 0.48 ppb level when “hot spots” in between Au nanoparticles are employed onto MIL‐100 (Fe) substrate, resulting in an enhancement factor of 10 10 . Additionally, we show that MIL‐100(Fe) substrate has a unique “sensor array” property allowing multiplex VOCs detection, with great modifiability and expandability by doping with foreign metal elements. Finally, the MIL‐100(Fe) platform is utilized to simultaneously detect the different gaseous indicators of lung cancer with a ppm detection limit, demonstrating its high potential for early diagnosis of lung cancer in vivo.