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Mitochondria‐Targeting Plasmonic Spiky Nanorods Increase the Elimination of Aging Cells in Vivo
Author(s) -
Lu Meiru,
Qu Aihua,
Li Si,
Sun Maozhong,
Xu Liguang,
Kuang Hua,
Xu Chuanlai
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202002576
Subject(s) - apoptosis , in vivo , mitochondrion , senescence , immune system , microbiology and biotechnology , reactive oxygen species , chemistry , nanorod , biophysics , programmed cell death , materials science , biology , nanotechnology , biochemistry , immunology
Cellular senescence is stress‐induced, irreversible growth arrest, and is thought to impair tissue function. The clearance of senescent cells can delay the features of senescence. Herein, we report the development of plasmonic core–shell spiky nanorods (CSNRs) surface‐modified with an anti‐beta‐2‐microglobulin (aB2MG) antibody and triphenylphosphonium (TPP), to target the mitochondria in senescent cells. aB2MG‐TPP@CSNRs irradiated with near‐infrared (NIR) light selectively caused mitochondrial damage and apoptosis of senescent cells with relatively low NIR light power, and the ability of CSNRs to activate and amplify the immune response in vitro and in vivo was discovered. The photo‐induced generation of reactive oxygen species (ROS) resulted in senescent‐cell apoptosis and immune adjuvant effect by CSNRs accelerated the clearance of senescent cells in mice. This study opens the way for the use of precisely regulated plasmonic nanostructures for immune adjuvant and photo‐induced apoptosis for age‐related senescence.