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A Photoinduced Nonadiabatic Decay‐Guided Molecular Motor Triggers Effective Photothermal Conversion for Cancer Therapy
Author(s) -
Ni JenShyang,
Zhang Xun,
Yang Guang,
Kang Tianyi,
Lin Xiangwei,
Zha Menglei,
Li Yaxi,
Wang Lidai,
Li Kai
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202002516
Subject(s) - photothermal therapy , molecular motor , chemistry , photothermal effect , intramolecular force , irradiation , conical intersection , small molecule , photochemistry , molecule , chemical physics , nanotechnology , materials science , stereochemistry , biochemistry , physics , organic chemistry , nuclear physics
It remains highly challenging to identify small molecule‐based photothermal agents with a high photothermal conversion efficiency (PTCE). Herein, we adopt a double bond‐based molecular motor concept to develop a new class of small photothermal agents to break the current design bottleneck. As the double‐bond is twisted by strong twisted intramolecular charge transfer (TICT) upon irradiation, the excited agents can deactivate non‐radiatively through the conical intersection (CI) of internal conversion, which is called photoinduced nonadiabatic decay. Such agents possess a high PTCE of 90.0 %, facilitating low‐temperature photothermal therapy in the presence of a heat shock protein 70 inhibitor. In addition, the behavior and mechanism of NIR laser‐triggered molecular motions for generating heat through the CI pathway have been further understood through theoretical and experimental evidence, providing a design principle for highly efficient photothermal and photoacoustic agents.