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Rhodium(III)‐Catalyzed Atroposelective Synthesis of Biaryls by C−H Activation and Intermolecular Coupling with Sterically Hindered Alkynes
Author(s) -
Wang Fen,
Qi Zisong,
Zhao Yuxia,
Zhai Shuailei,
Zheng Guangfan,
Mi Ruijie,
Huang Zhiyan,
Zhu Xiaolin,
He Xiaoming,
Li Xingwei
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202002208
Subject(s) - chemistry , annulation , steric effects , alkyne , regioselectivity , intermolecular force , catalysis , amide , enantiomer , rhodium , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , molecule
Reported herein is the atroposelective synthesis of biaryl NH isoquinolones by Rh III ‐catalyzed C−H activation of benzamides and intermolecular [4+2] annulation for a broad scope of 2‐substituted 1‐alkynylnaphthalenes, as well as sterically hindered, symmetric diarylacetylenes. The axial chirality is constructed based on dynamic kinetic transformation of the alkyne in redox‐neutral annulation with benzamides, with alkyne insertion being stereodetermining. The reaction accommodates both benzamides and heteroaryl carboxamides and proceeds in excellent regioselectivity (if applicable) and enantioselectivities (average 91.8 % ee ). An enantiomerically and diastereomerically pure rhodacyclic complex was prepared and offers insight into enantiomeric control of the coupling system, wherein the steric interactions between the amide directing group and the alkyne substrate dictate both the regio‐ and enantioselectivity.