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Light‐Induced Chiral Iron Copper Selenide Nanoparticles Prevent β‐Amyloidopathy In Vivo
Author(s) -
Zhang Hongyu,
Hao Changlong,
Qu Aihua,
Sun Maozhong,
Xu Liguang,
Xu Chuanlai,
Kuang Hua
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202002028
Subject(s) - photothermal therapy , reactive oxygen species , nanoparticle , chemistry , copper , monomer , in vivo , irradiation , biophysics , materials science , nanotechnology , biochemistry , organic chemistry , polymer , physics , microbiology and biotechnology , nuclear physics , biology
The accumulation and deposition of β‐amyloid (Aβ) plaques in the brain is considered a potential pathogenic mechanism underlying Alzheimer's disease (AD). Chiral l/d ‐Fe x Cu y Se nanoparticles (NPs) were fabricated that interfer with the self‐assembly of Aβ42 monomers and trigger the Aβ42 fibrils in dense structures to become looser monomers under 808 nm near‐infrared (NIR) illumination. d ‐Fe x Cu y Se NPs have a much higher affinity for Aβ42 fibrils than l ‐Fe x Cu y Se NPs and chiral Cu 2− x Se NPs. The chiral Fe x Cu y Se NPs also generate more reactive oxygen species (ROS) than chiral Cu 2− x Se NPs under NIR‐light irradiation. In living MN9D cells, d ‐NPs attenuate the adhesion of Aβ42 to membranes and neuron loss after NIR treatment within 10 min without the photothermal effect. In‐vivo experiments showed that d ‐Fe x Cu y Se NPs provide an efficient protection against neuronal damage induced by the deposition of Aβ42 and alleviate symptoms in a mouse model of AD, leading to the recovery of cognitive competence.