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Diastereo‐ and Enantioselective 1,4‐Difunctionalization of Borylenynes by Catalytic Conjunctive Cross‐Coupling
Author(s) -
Law Chunyin,
Kativhu Elton,
Wang Johnny,
Morken James P.
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202001580
Subject(s) - enantioselective synthesis , electrophile , chemistry , chirality (physics) , catalysis , axial chirality , combinatorial chemistry , product (mathematics) , stereochemistry , organic chemistry , physics , mathematics , chiral symmetry breaking , geometry , quantum mechanics , nambu–jona lasinio model , quark
Enantioselective conjunctive cross‐coupling of enyne‐derived boronate complexes occurs with 1,4 addition of the electrophile and migrating group across the π system. This reaction pathway furnishes α‐boryl allenes as the reaction product. In the presence of a chiral catalyst, both the central and axial chirality of the product can be controlled during product formation.