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Chiral Aluminum Complex Controls Enantioselective Nickel‐Catalyzed Synthesis of Indenes: C−CN Bond Activation
Author(s) -
Zhang Tao,
Luan YuXin,
Zheng SuJuan,
Peng Qian,
Ye Mengchun
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202001142
Subject(s) - enantioselective synthesis , chemistry , nickel , catalysis , aryl , domino , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , alkyl
A chiral aluminum complex controlled, enantioselective nickel‐catalyzed domino reaction of aryl nitriles and alkynes proceeding by C−CN bond activation was developed. The reaction provides various indenes, bearing chiral all‐carbon quaternary centers, under mild reaction conditions in yields of 32 to 91 % and ee values within the 73–98 % range. The reaction mechanism and aspects of stereocontrol were investigated by DFT calculations.