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FeOOH@Metal–Organic Framework Core–Satellite Nanocomposites for the Serum Metabolic Fingerprinting of Gynecological Cancers
Author(s) -
Pei Congcong,
Liu Chao,
Wang You,
Cheng Dan,
Li Rongxin,
Shu Weikang,
Zhang Chaoqi,
Hu Wenli,
Jin Aihua,
Yang Yannan,
Wan Jingjing
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202001135
Subject(s) - mass spectrometry , desorption , metabolomics , chemistry , ionization , metabolic disease , nanocomposite , chromatography , medicine , materials science , nanotechnology , organic chemistry , adsorption , ion
High‐throughput metabolic analysis is of significance in diagnostics, while tedious sample pretreatment has largely hindered its clinic application. Herein, we designed FeOOH@ZIF‐8 composites with enhanced ionization efficiency and size‐exclusion effect for laser desorption/ionization mass spectrometry (LDI‐MS)‐based metabolic diagnosis of gynecological cancers. The FeOOH@ZIF‐8‐assisted LDI‐MS achieved rapid, sensitive, and selective metabolic fingerprints of the native serum without any enrichment or purification. Further analysis of extracted serum metabolic fingerprints successfully discriminated patients with gynecological cancers (GCs) from healthy controls and also differentiated three major subtypes of GCs. Given the low cost, high‐throughput, and easy operation, our approach brings a new dimension to disease analysis and classification.