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Improved Acid Resistance of a Metal–Organic Cage Enables Cargo Release and Exchange between Hosts
Author(s) -
Xu Lin,
Zhang Dawei,
Ronson Tanya K.,
Nitschke Jonathan R.
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202001059
Subject(s) - cage , chemistry , affinities , ketone , metal , zinc , tetrahedron , pyridine , stereochemistry , polymer chemistry , combinatorial chemistry , crystallography , organic chemistry , mathematics , combinatorics
The use of di(2‐pyridyl)ketone in subcomponent self‐assembly is introduced. When combined with a flexible triamine and zinc bis(trifluoromethanesulfonyl)imide, this ketone formed a new Zn 4 L 4 tetrahedron 1 bearing twelve uncoordinated pyridyl units around its metal‐ion vertices. The acid stability of 1 was found to be greater than that of the analogous tetrahedron 2 built from 2‐formylpyridine. Intriguingly, the peripheral presence of additional pyridine rings in 1 resulted in distinct guest binding behavior from that of 2 , affecting guest scope as well as binding affinities. The different stabilities and guest affinities of capsules 1 and 2 enabled the design of systems whereby different cargoes could be moved between cages using acid and base as chemical stimuli.