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Fabrication of Pascal‐triangle Lattice of Proteins by Inducing Ligand Strategy
Author(s) -
Liu Rongying,
Kochovski Zdravko,
Li Long,
Yin Yuewen,
Yang Jing,
Yang Guang,
Tao Guoqing,
Xu Anqiu,
Zhang Ensong,
Ding Hongming,
Lu Yan,
Chen Guosong,
Jiang Ming
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202000771
Subject(s) - pascal (unit) , supramolecular chemistry , ligand (biochemistry) , crystallography , crystal structure , chemistry , nanotechnology , materials science , computer science , biochemistry , programming language , receptor
A protein Pascal triangle has been constructed as new type of supramolecular architecture by using the inducing ligand strategy that we previously developed for protein assemblies. Although mathematical studies on this famous geometry have a long history, no work on such Pascal triangles fabricated from native proteins has been reported so far due to their structural complexity. In this work, by carefully tuning the specific interactions between the native protein building block WGA and the inducing ligand R‐SL , a 2D Pascal‐triangle lattice with three types of triangular voids has been assembled. Moreover, a 3D crystal structure was obtained based on the 2D Pascal triangles. The distinctive carbohydrate binding sites of WGA and the intralayer as well as interlayer dimerization of RhB was the key to facilitate nanofabrication in solution. This strategy may be applied to prepare and explore various sophisticated assemblies based on native proteins.