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Water‐Soluble Non‐Classical Benzene Mimetics
Author(s) -
Levterov Vadym V.,
Panasyuk Yaroslav,
Pivnytska Valentyna O.,
Mykhailiuk Pavel K.
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202000548
Subject(s) - benzene , solubility , pentane , chemistry , water soluble , bicyclic molecule , stereochemistry , organic chemistry , medicinal chemistry
A new generation of saturated benzene mimetics, 2‐oxabicyclo[2.1.1]hexanes, was developed. These compounds were designed as analogues of bicyclo[1.1.1]pentane with an improved water solubility. Crystallographic analysis of 2‐oxabicyclo[2.1.1]hexanes revealed that they occupy a novel chemical space, but, at the same time, resemble the motif of meta ‐disubstituted benzenes.
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