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Protein‐Structure‐Directed Metal–Organic Zeolite‐like Networks as Biomacromolecule Carriers
Author(s) -
Wang Huanrong,
Han Lin,
Zheng Dong,
Yang Mingfang,
Andaloussi Yassin H.,
Cheng Peng,
Zhang Zhenjie,
Ma Shengqian,
Zaworotko Michael J.,
Feng Yifan,
Chen Yao
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202000299
Subject(s) - sodalite , chemistry , biocatalysis , zeolite , metal organic framework , diamondoid , nanotechnology , pyrococcus furiosus , combinatorial chemistry , topology (electrical circuits) , catalysis , organic chemistry , materials science , biochemistry , molecule , adsorption , archaea , reaction mechanism , mathematics , combinatorics , gene
Fabrication of zeolite‐like metal–organic frameworks (ZMOFs) for advanced applications, such as enzyme immobilization, is of great interest but is a great synthetic challenge. Herein, we have developed a new strategy using proteins as structure‐directed agents to direct the formation of new ZMOFs that can act as versatile platforms for the in situ encapsulation of proteins under ambient conditions. Notably, protein incorporation directs the formation of a ZMOF with a sodalite ( sod ) topology instead of a non‐porous diamondoid ( dia ) topology under analogous synthetic conditions. Histidines in proteins play a crucial role in the observed templating effect. Modulating histidine content thereby influenced the resultant MOF product (from dia to dia + sod mixture and, ultimately, to sod MOF). Moreover, the resulting ZMOF‐incorporated proteins preserved their activity even after exposure to high temperatures and organic solvents, demonstrating their potential for biocatalysis and biopharmaceutical applications.