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Large Deformation of a DNA‐Origami Nanoarm Induced by the Cumulative Actuation of Tension‐Adjustable Modules
Author(s) -
Suzuki Yuki,
Kawamata Ibuki,
Mizuno Kohei,
Murata Satoshi
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201916233
Subject(s) - flexibility (engineering) , deformation (meteorology) , tension (geology) , materials science , dna origami , dna , compliant mechanism , nanotechnology , structural engineering , chemistry , composite material , nanostructure , engineering , ultimate tensile strength , mathematics , finite element method , biochemistry , statistics
Making use of the programmability and structural flexibility of the DNA molecule, a DNA‐origami nanoarm capable of undergoing large deformation is constructed. This DNA‐origami nanoarm comprised serially repeated tension‐adjustable modules, the cumulative actuation of which resulted in a large deformation of the arm structure, which transformed from a linear shape into an arched shape. Combining atomic force microscopy and theoretical analyses based on the mechanics of materials, we demonstrate that the degree of deformation can be systematically controlled by merely replacing a set of strands that is required for the actuation of the module. Moreover, by employing a G‐quadruplex‐forming sequence for the actuation, we could achieve reversible ion‐induced contraction and relaxation of the nanoarm. The adjustability and scalability of this design could enable the production of DNA nanodevices that exhibit large deformation in response to external stimuli.