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Supramolecular Phthalocyanine Assemblies for Improved Photoacoustic Imaging and Photothermal Therapy
Author(s) -
Li Xingshu,
Park EunYeong,
Kang Youngnam,
Kwon Nahyun,
Yang Mengyao,
Lee Seunghyun,
Kim Won Jong,
Kim Chulhong,
Yoon Juyoung
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201916147
Subject(s) - photothermal therapy , photoacoustic imaging in biomedicine , singlet oxygen , phthalocyanine , supramolecular chemistry , nanotechnology , materials science , nanostructure , cancer therapy , fluorescence , fluorescence lifetime imaging microscopy , chemistry , cancer , molecule , organic chemistry , oxygen , optics , medicine , physics
Phototheranostic nanoplatforms are of particular interest for cancer diagnosis and imaging‐guided therapy. Herein, we develop a supramolecular approach to fabricate a nanostructured phototheranostic agent through the direct self‐assembly of two water‐soluble phthalocyanine derivatives, PcS4 and PcN4. The nature of the molecular recognition between PcS4 and PcN4 facilitates the formation of nanostructure (PcS4‐PcN4) and consequently enables the fabrication of PcS4‐PcN4 with completely quenched fluorescence and reduced singlet oxygen generation, leading to the high photoacoustic and photothermal activity of PcS4‐PcN4. In vivo evaluations suggest that PcS4‐PcN4 could not only efficiently visualize a tumor with high contrast through whole‐body photoacoustic imaging but also enable excellent photothermal therapy for cancer.