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Rational Chemical Multifunctionalization of Graphene Interface Enhances Targeted Cancer Therapy
Author(s) -
Lucherelli Matteo Andrea,
Yu Yue,
Reina Giacomo,
Abellán Gonzalo,
Miyako Eijiro,
Bianco Alberto
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201916112
Subject(s) - graphene , photothermal therapy , surface modification , rational design , doxorubicin , drug delivery , nanotechnology , folic acid , chemistry , cancer therapy , targeted drug delivery , anticancer drug , cancer cell , materials science , combinatorial chemistry , drug , cancer , pharmacology , chemotherapy , medicine , surgery
The synthesis of a drug delivery platform based on graphene was achieved through a step‐by‐step strategy of selective amine deprotection and functionalization. The multifunctional graphene platform, functionalized with indocyanine green, folic acid, and doxorubicin showed an enhanced anticancer activity. The remarkable targeting capacity for cancer cells in combination with the synergistic effect of drug release and photothermal properties prove the great advantage of a combined chemo‐ and phototherapy based on graphene against cancer, opening the doors to future therapeutic applications of this type of material.