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Genetically Encoded Activators of Small Molecules for Imaging and Drug Delivery
Author(s) -
Thiel Zacharias,
Nguyen Jade,
RiveraFuentes Pablo
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201915521
Subject(s) - computational biology , synthetic biology , drug discovery , computer science , nanotechnology , drug delivery , chemical biology , data science , biochemical engineering , chemistry , biology , bioinformatics , materials science , engineering , biochemistry
Chemical biologists have developed many tools based on genetically encoded macromolecules and small, synthetic compounds. The two different approaches are extremely useful, but they have inherent limitations. In this Minireview, we highlight examples of strategies that combine both concepts to tackle challenging problems in chemical biology. We discuss applications in imaging, with a focus on super‐resolved techniques, and in probe and drug delivery. We propose future directions in this field, hoping to inspire chemical biologists to develop new combinations of synthetic and genetically encoded probes.