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Fabrication of Microporous Metal–Organic Frameworks in Uninterrupted Mesoporous Tunnels: Hierarchical Structure for Efficient Trypsin Immobilization and Stabilization
Author(s) -
Lu Jie,
Wu JuKang,
Jiang Yao,
Tan Peng,
Zhang Lin,
Lei Yu,
Liu XiaoQin,
Sun LinBing
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201915332
Subject(s) - mesoporous material , microporous material , metal organic framework , materials science , chemical engineering , porosity , nanotechnology , adsorption , mesoporous organosilica , molecule , mesoporous silica , chemistry , organic chemistry , composite material , catalysis , engineering
Hierarchically porous metal–organic frameworks (HP‐MOFs) are promising in various applications. Most reported HP‐MOFs are prepared based on the generation of mesopores in microporous frameworks, and the formed mesopores are connected by microporous channels, limiting the accessibility of mesopores for bulky molecules. A hierarchical structure is formed by constructing microporous MOFs in uninterrupted mesoporous tunnels. Using the confined space in as‐prepared mesoporous silica, highly dispersed metal precursors for MOFs are coated on the internal surface of mesoporous tunnels. Ligand vapor‐induced crystallization is employed to enable quantitative formation of MOFs in situ, in which sublimated ligands diffuse into mesoporous tunnels and react with metal precursors. The obtained hierarchically porous composites exhibit record‐high adsorption capacity for the bulky molecule trypsin. The thermal and storage stability of trypsin is improved upon immobilization on the composites.