Premium
Self‐Amplified Photodynamic Therapy through the 1 O 2 ‐Mediated Internalization of Photosensitizers from a Ppa‐Bearing Block Copolymer
Author(s) -
Liu Zhiyong,
Cao Tianye,
Xue Yudong,
Li Mengting,
Wu Mengsi,
Engle Jonathan W.,
He Qianjun,
Cai Weibo,
Lan Minbo,
Zhang Weian
Publication year - 2020
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201914434
Subject(s) - photodynamic therapy , singlet oxygen , photosensitizer , nanocarriers , copolymer , chemistry , fluorescence , photochemistry , nanotechnology , nanoparticle , materials science , organic chemistry , oxygen , optics , polymer , physics
Nanocarriers are employed to deliver photosensitizers for photodynamic therapy (PDT) through the enhanced penetration and retention effect, but disadvantages including the premature leakage and non‐selective release of photosensitizers still exist. Herein, we report a 1 O 2 ‐responsive block copolymer (POEGMA‐ b ‐P(MAA‐ co ‐VSPpaMA) to enhance PDT via the controllable release of photosensitizers. Once nanoparticles formed by the block copolymer have accumulated in a tumor and have been taken up by cancer cells, pyropheophorbide a (Ppa) could be controllably released by singlet oxygen ( 1 O 2 ) generated by light irradiation, enhancing the photosensitization. This was demonstrated by confocal laser scanning microscopy and in vivo fluorescence imaging. The 1 O 2 ‐responsiveness of POEGMA‐ b ‐P(MAA‐ co ‐VSPpaMA) block copolymer enabled the realization of self‐amplified photodynamic therapy by the regulation of Ppa release using NIR illumination. This may provide a new insight into the design of precise PDT.